123 results
-
A distinct type of astrocytic pathology characterized by the presence of dense, argyrophilic (silver stain-positive) phosphorylated tau-immunopositive inclusions within the proximal processes of astrocytes. Tufted astrocytes are a histopathological hallmark of PSP.
Reference:
Kovacs GG. Astroglia and tau: new perspectives. Front Aging Neurosci. 2020;12:96. doi:10.3389/fnagi.2020.00096
-
Aspects of care or disease management that currently have no adequate solutions (such as misdiagnosis or lack of curative therapies in the case of PSP).
Reference:
Vreman RA, Heikkinen I, Schuurman A, et al. Unmet medical need: an introduction to definitions and stakeholder perceptions. Value Health. 2019;22(11):1275-1282. doi:10.1016/j.jval.2019.07.007
-
A magnetic resonance imaging technique that quantifies the volume of specific brain structures to assess structural changes over time.
Reference:
Blair S. MRI studies of the brain [Internet]. Brain Injury Law of Seattle. [cited 2025 Nov]. Available from: https://www.braininjurylawofseattle.com/what-is-a-volumetric-analysis-of-the-brain/
