4 results
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Refers to the quantifiable use of healthcare services and resources, including hospitalizations, outpatient visits, emergency department visits, medication prescriptions, use of medical devices, allied health services, and home care. HCRU is a key metric in health services research and health economics, used to assess disease burden, plan resource allocation, and evaluate the impact of interventions on healthcare systems.
Reference:
Stenson K, O'Callaghan L, Mellor J, Wright J, Gibson G, Earl L, Barlow S, Fournier CN. Healthcare resource utilization at different stages of amyotrophic lateral sclerosis: results from a real-world survey. J Neurol Sci. 2023 Sep 15;452:120764. doi:10.1016/j.jns.2023.120764 | York Health Economics Consortium. Resource use [Internet]. [cited 2025 Dec]. Available from: https://www.yhec.co.uk/glossary-term/resource-use/
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Tau protein with an excessive number of phosphate groups attached, causing it to detach from microtubules, misfold, and aggregate into toxic NFTs that disrupt neuronal function.
Reference:
Tapia-Rojas C, Cabezas-Opazo F, Deaton CA, Vergara EH, Johnson GVW, Quintanilla RA. It's all about tau. Prog Neurobiol. 2019;175:54-76. doi:10.1016/j.pneurobio.2018.12.005
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Significant impairment in the ability to perform normal motor actions.
Reference:
ScienceDirect Topics. Hypokinesia [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/hypokinesia
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A reduction in glucose uptake and energy activity in specific brain regions, seen as areas of low tracer signal on FDG-PET, usually reflecting neuronal dysfunction or loss.
Reference:
National Center for Biotechnology Information (NCBI). MedGen: Hypometabolism [Internet]. [cited 2025 Nov]. Available from: https://www.ncbi.nlm.nih.gov/medgen/868403
