5 results

• Gait freezing

  Sudden and transient inability to initiate walking, often described as the feet being “glued” to the floor.

  Reference:

  Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987

• Gene

  A segment of genetic material (or DNA) that determines inherited characteristics and contributes to the organism’s physiological functions.

  Reference:

  ScienceDirect Topics. Gene [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/gene

• Genetic loci/ locus

  The specific physical location of a gene or other DNA sequence on a chromosome.

  Reference:

  ScienceDirect Topics. Gene locus [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/gene-locus

• Genome-wide association studies

  A research method that examines the entire genome (the complete set of DNA of a person) to detect genetic variants linked to a specific trait or disease.

  Reference:

  ScienceDirect Topics. Genome-wide association study [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/genome-wide-association-study

• Glial fibrillary acidic protein (GFAP)

  A protein expressed almost exclusively in astrocytes, used as a biomarker of astrocyte injury and neuroinflammation.

  Reference:

  Chouliaras L, Thomas A, Malpetti M, et al. Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2022;93(6):651-658. doi:10.1136/jnnp-2021-327788