9 results

• Dementia

  A loss of global cognitive ability that interferes with normal social or occupational function.

  Reference:

  ScienceDirect Topics. Dementia [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/dementia

• Differential diagnosis

  The process of distinguishing a disease from other conditions with similar clinical features. In PSP, it involves differentiating it from disorders such as Parkinson’s disease or other PSP-mimicking syndromes.

  Reference:

  Krzosek P, Madetko N, Migda A, et al. Differential diagnosis of rare subtypes of progressive supranuclear palsy and PSP-like syndromes. Front Aging Neurosci. 2022;14:804385. doi:10.3389/fnagi.2022.804385

• Disability adjusted life year (DALY)

  is a generic measure of health outcome that can be used in cost utility analysis. DALYs are a measure of overall disease burden, expressed as the number of years lost due to ill health, disability or mortality.

  Reference:

  Cochrane Economics Methods Group. Glossary of terms for health economics and systematic review [Internet]. [cited 2025 Dec]. Available from: https://methods.cochrane.org/economics/methods-training/glossary

• Disease burden

  The overall impact of a disease on patients, caregivers, and healthcare systems – including physical, emotional, social, and economic effects.

  Reference:

  Springer Nature. Burden of disease [Internet]. [cited 2025 Nov]. Available from: https://link.springer.com/rwe/10.1007/978-1-4020-5614-7_297

• Disease-modifying therapy (DMT)

  A treatment aimed at addressing the underlying cause and altering its natural progression. These work by targeting the root mechanisms that drive the disease, potentially slowing down, halting or even reversing its course.

  Reference:

  Cummings JL. Defining and labeling disease-modifying treatments for Alzheimer's disease. Alzheimers Dement. 2009;5(5):406-418. doi:10.1016/j.jalz.2008.12.003

• Double-blind

  A study design where neither participants nor researchers know which treatment each participant receives, reducing the likelihood of bias in the results.

  Reference:

  Harvard Health. Medical dictionary of health terms: D through I [Internet]. [cited 2025 Nov]. Available from: https://www.health.harvard.edu/d-through-i

• Dysarthria

  A speech disorder of neurological origin marked by impaired articulation.

  Reference:

  ScienceDirect Topics. Dysarthria [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/dysarthria

• Dysgeusia

  An alteration or distortion in the normal sense of taste.

  Reference:

  ScienceDirect Topics. Dysgeusia [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/nursing-and-health-professions/dysgeusia

• Dysphagia

  Difficulty swallowing that often requires changes in diet. Some individuals with dysphagia struggle with certain foods or liquids, while others are unable to swallow at all. Additional signs may include coughing or choking during meals, regurgitating food, feeling as though food is stuck in the throat or chest, and continuous drooling.

  Reference:

  NHS inform. Dysphagia (swallowing problems) [Internet]. [cited 2025 Nov]. Available from: https://www.nhsinform.scot/illnesses-and-conditions/stomach-liver-and-gastrointestinal-tract/dysphagia-swallowing-problems/