10 results

• Macro square wave jerks

  Involuntary, large-amplitude, horizontal eye movements that temporarily move the eyes away from and then back to a fixation point.

  Reference:

  Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987

• Mechanism of action (MoA)

  The specific physiological process through which a drug produces its therapeutic effect in the body.

  Reference:

  Cirinciani M, Da Pozzo E, Trincavelli ML, et al. Drug mechanism: a bioinformatic update. Biochem Pharmacol. 2024;228:116078. doi:10.1016/j.bcp.2024.116078

• Mentation

  Refers to cognitive and mental functioning, such as thinking, memory, attention and judgement.

  Reference:

  Golbe LI, Ohman-Strickland PA. A clinical rating scale for progressive supranuclear palsy. Brain. 2007;130(Pt 6):1552-1565. doi:10.1093/brain/awm032

• Microtubules (MTs)

  Cylindrical protein filaments forming part of the cell’s cytoskeleton, essential for maintaining cell shape, intracellular transport, and cell division.

  Reference:

  Kapitein LC, Hoogenraad CC. Building the neuronal microtubule cytoskeleton. Neuron. 2015;87(3):492-506. doi:10.1016/j.neuron.2015.05.046

• Misdiagnosis

  An incorrect identification of a disease, often leading to inappropriate treatment or delays in receiving appropriate treatment.

  Reference:

  ScienceDirect Topics. Misdiagnosis [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/psychology/misdiagnosis

• Monoclonal antibodies (mAb)

  Laboratory-produced antibodies engineered to recognize and bind specific antigens.

  Reference:

  ScienceDirect Topics. Monoclonal antibody [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/monoclonal-antibody

• Mortality

  In medicine, the term is used as the number of deaths in a population during a specific period of time.

  Reference:

  ScienceDirect Topics. Mortality [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/mortality

• Movement disorders (MD)

  Group of neurological conditions primarily affecting the control of voluntary and involuntary movements, resulting in symptoms such as stiffness, slowness or tremors.

  Reference:

  ScienceDirect Topics. Movement disorder [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/movement-disorder

• Multidisciplinary

  An integrated approach to care provided by a team of specialists. In the case of PSP, the multidisciplinary team may include, but are not limited to: neurologist, nurses, physiotherapist, speech therapist, psychologist, dietician, social worker, etc.

  Reference:

  Rowe JB, Holland N, Rittman T. Progressive supranuclear palsy: diagnosis and management. Pract Neurol. 2021;21(5):376-383. doi:10.1136/practneurol-2020-002794

• Myoclonus

  Brief, involuntary muscle contractions.

  Reference:

  ScienceDirect Topics. Myoclonus [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/myoclonus