6 results

• Economic burden

  In the medical context refers to the total financial impact that a disease or health condition imposes on individuals, households, healthcare systems, and society. This burden is typically divided into direct costs (such as expenditures for medical care, hospitalizations, medications, diagnostic tests, and preventive actions) and indirect costs (including lost productivity, absenteeism, presenteeism, loss of income, and premature death).

  Reference:

  LaVeist TA, Pérez-Stable EJ, Richard P, et al. The economic burden of racial, ethnic, and educational health inequities in the US. JAMA. 2023;329(19):1682-1692. doi:10.1001/jama.2023.5965

• Efficacy

  The ability of an intervention to produce the intended effect under controlled study conditions.)

  Reference:

  EU Clinical Trials Register. Glossary [Internet]. [cited 2025 Nov]. Available from: https://www.clinicaltrialsregister.eu/doc/EU_Clinical_Trials_Register_Glossary.pdf

• Endpoint

  A predefined variable or outcome used to evaluate the effect, safety, or other impact of a treatment or intervention. For example, the primary efficacy endpoint in PROSPER is the change from baseline to Week 52 on the PSP Rating Scale (PSPRS).

  Reference:

  EU Clinical Trials Register. Glossary [Internet]. [cited 2025 Nov]. Available from: https://www.clinicaltrialsregister.eu/doc/EU_Clinical_Trials_Register_Glossary.pdf | ClinicalTrials.gov. PROSPER (NCT06355531) [Internet]. [cited 2025 Nov]. Available from: https://clinicaltrials.gov/study/NCT06355531

• Epigenetic

  Refers to heritable changes that do not affect the DNA sequence but influence gene expression (e.g., chemical modifications).

  Reference:

  ScienceDirect Topics. Epigenetics [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/epigenetics

• Extracellular

  Located or occurring outside the cell.

  Reference:

  ScienceDirect Topics. Extracellular space [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/extracellular-space

• Eyelid opening apraxia

  Inability to voluntarily open the eyelids after they have been closed for a period of time.

  Reference:

  Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987