PSP GLOSSARY

Explore the key definitions and concepts behind PSP. This glossary will help you better understand its terminology and navigate it with confidence.

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  • A diagnosis reinforced by findings from imaging techniques (e.g., MRI, PET) that show disease-specific changes.

    Reference:

    Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987

  • A type of therapy based on stimulating or suppressing the immune system.

    Reference:

    Harvard Health. Medical dictionary of health terms: D through I [Internet]. [cited 2025 Nov]. Available from: https://www.health.harvard.edu/d-through-i

  • The number of new cases of a disease occurring in a specific population over a specific period of time.

    Reference:

    ScienceDirect Topics. Incidence (epidemiology) [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/incidence-epidemiology

  • Located or occurring within the interior of a cell.

    Reference:

    ScienceDirect Topics. Intracellular fluid [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/intracellular-fluid

  • Variants of a protein that can slightly differ in structure and function. E.g. tau can appear as 3R and 4R.

    Reference:

    ScienceDirect Topics. Gene isoform [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/gene-isoform | Zhang Y, Wu KM, Yang L, Dong Q, Yu JT. Tauopathies: new perspectives and challenges. Mol Neurodegener. 2022;17(1):28. doi:10.1186/s13024-022-00533-z