24 results

• Postsynaptic striatal dopaminergic degeneration

  Loss or dysfunction of dopamine-receiving neurons in the striatum, leading to impaired motor signaling.

  Reference:

  Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987

• Preclinical

  Research conducted before testing in humans, using laboratory and animal studies to evaluate the pharmacological, toxicological, and pharmacokinetic properties of a drug.

  Reference:

  ScienceDirect Topics. Preclinical study [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/preclinical-study

• Presymptomatic

  Stage where the disease is already present in the brain, but no symptoms are visible yet.

  Reference:

  Boxer AL, Yu JT, Golbe LI, Litvan I, Lang AE, Höglinger GU. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. Lancet Neurol. 2017;16(7):552-563. doi:10.1016/S1474-4422(17)30157-6

• Prevalence

  The total number of cases of a disease in a population at a specific point in time or over a defined period.

  Reference:

  ScienceDirect Topics. Prevalence [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/prevalence

• Prion-like propagation

  Process in which abnormal proteins (e.g., NFTs) spread from cell to cell, converting healthy proteins into the same harmful form and spreading the disease throughout the brain.

  Reference:

  Kammula SV, Tripathi S, Wang N, et al. Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer’s disease. Ageing Neur Dis. 2023;3(4). doi:10.20517/and.2023.20

• Prognosis

  The predicted outcome of a disease, including likelihood of recovery or recurrence.

  Reference:

  ScienceDirect Topics. Prognosis [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/nursing-and-health-professions/prognosis

• Progressive (disease)

  A disease that worsens over time in terms of extent or severity.

  Reference:

  National Center for Biotechnology Information (NCBI). MedGen: Progressive disease [Internet]. [cited 2025 Nov]. Available from: https://www.ncbi.nlm.nih.gov/medgen/277534

• PROSPER

  PROSPER is an ongoing multinational, randomised, double-blind, placebo-controlled Phase 2 study to assess the safety, tolerability and efficacy of FNP-223 administered orally at a dose of 300 mg three times a day in adults aged 50–80 years with early-stage possible or probable PSP-RS.

  Reference:

  ClinicalTrials.gov. PROSPER (NCT06355531) [Internet]. [cited 2025 Nov]. Available from: https://clinicaltrials.gov/study/NCT06355531

• Protein aggregation

  Process in which misfolded proteins clump together, forming toxic deposits in the brain, like tau in tauopathies.

  Reference:

  Zhang Y, Wu KM, Yang L, Dong Q, Yu JT. Tauopathies: new perspectives and challenges. Mol Neurodegener. 2022;17(1):28. doi:10.1186/s13024-022-00533-z